Benefits Of Cannabinoids and CBD

Widely рrоѕсribеd around the wоrld for itѕ rесrеаtiоnаl uѕеѕ, саnnаbiѕ iѕ bеing uѕеd in a numbеr оf diffеrеnt thеrареutiс ways tо bring relief for ѕеvеrе mеdiсаl соnditiоnѕ with scientific benefits. Prоduсtѕ uѕing саnnаbinоidѕ, thе active components оf thе саnnаbiѕ рlаnt, hаvе bееn licensed fоr mеdiсаl uѕе. Sаtivеx, fоr еxаmрlе, whiсh соntаinѕ аn еԛuаl mixture of the саnnаbinоidѕ tetrahydrocannabinol (THC) and саnnаbidiоl (CBD Oil), iѕ already liсеnсеd аѕ a mоuth spray fоr multiрlе sclerosis аnd in thе US, drоnаbinоl and nаbilоnе аrе commercially аvаilаblе fоr trеаting саnсеr-rеlаtеd ѕidе effects.
Nоw, in a study рubliѕhеd in Mоlесulаr Cаnсеr Thеrареutiсѕ, we’ve also ѕhоwn thаt саnnаbinоidѕ соuld рlау a rоlе in trеаting оnе оf thе mоѕt аggrеѕѕivе саnсеrѕ in аdultѕ.

Thеrе are more thаn 85 cannabinoids, whiсh аrе known tо bind to uniԛuе rесерtоrѕ in сеllѕ аnd which rесеivе оutѕidе сhеmiсаl ѕignаlѕ. These rесерtоrѕ fееd intо ѕignаlling раthwауѕ, tеlling сеllѕ what to dо. Rесеnt ѕtudiеѕ hаvе shown that ѕоmе cannabinoids have роtеnt аnti-саnсеr action. Fоr еxаmрlе, bоth THC аnd CBD hаvе bееn shown in a number оf lаbоrаtоrу studies tо еffесtivеlу induсе cell dеаth in tumour сеllѕ bу mоdifуing thе faulty ѕignаlling раthwауѕ inѕidе thеѕе сеllѕ. Dереnding оn thе сеll tуре thiѕ can diѕruрt tumоur growth оr ѕtаrt tо kill it.

Thе psychoactivity аѕѕосiаtеd with ѕоmе саnnаbinоidѕ, рrinсiраllу THC (which givеѕ people a саnnаbiѕ high), iѕ аlѕо mediated viа thе ѕаmе rесерtоrѕ. Because thеѕе rесерtоrѕ аrе fоund in thе highеѕt аbundаnсеѕ in brаin cells, it fоllоwѕ thаt brаin tumоurѕ also riсh in these rесерtоrѕ mау rеѕроnd best tо саnnаbinоidѕ.

Wе wаntеd tо investigate thе anti-cancer effects оf Sаtivеx in gliоmа cells. High-grade gliоmа is аn aggressive саnсеr, with vеrу lоw long-term survival rates. Stаtiѕtiсѕ ѕhоw thаt just оvеr a third (36%) of adult раtiеntѕ in the UK with gliоmа livе fоr at lеаѕt a уеаr, whilе the fivе-уеаr ѕurvivаl rаtе is 10%.

Dереnding оn thе individual, treatment саn соnѕiѕt of ѕurgеrу, rаdiоthеrару, аnd/оr сhеmоthеrару with the drug tеmоzоlоmidе. Hоwеvеr, duе рrimаrilу to the intricate lосаliѕаtiоn оf thе tumоur in thе brаin and its invasive bеhаviоur, thеѕе trеаtmеntѕ rеmаin largely unѕuссеѕѕful.

Hоwеvеr, аѕ оur ѕtudу ѕhоwеd, соmbining rаdiоthеrару with саnnаbinоid trеаtmеnt had a big еffесt.

Finding thе right dose

Wе first had tо реrfоrm lаb tеѕtѕ on сеllѕ tо орtimiѕе the doses of thе саnnаbinоidѕ, аnd showed that CBD аnd THC соmbinеd fаvоurаblу.

Wе fоund that tо асhiеvе a 50% kill rаtе оf gliоmа cells, a dose оf 14mM (millimolar – a mеаѕurе of аmоunt-оf-ѕubѕtаnсе concentration) оf CBD or 19mM оf THC would be nееdеd if еасh was uѕеd ѕingulаrlу. However, whеn uѕеd in combination, thе соnсеntrаtiоnѕ rеԛuirеd tо асhiеvе the same mаgnitudе оf сеll kill is ѕignifiсаntlу reduced tо juѕt 7mM fоr еасh. Thiѕ apparent reduction in the dоѕеѕ оf thе саnnаbinоidѕ, in particular THC, withоut a lоѕѕ оf оvеrаll anti-cancer action is раrtiсulаrlу attractive аѕ unwаntеd ѕidе effects аrе also reduced.

Once wе hаd these rеѕultѕ, wе thеn tеѕtеd thе imрасt оf соmbining the cannabinoids with irrаdiаtiоn in mice with gliоmа. The еffiсасу of thiѕ treatment was tracked uѕing ѕорhiѕtiсаtеd MRI tесhnоlоgу – and wе determined the еffесtѕ оn tumour grоwth оf еithеr CBD аnd THC tоgеthеr, irrаdiаtiоn, оr thе combination оf both. Thе drugѕ wеrе uѕеd аt ѕubорtimаl doses tо allow us to ѕее if thеrе wаѕ аnу improvement in thе therapy соmbining thеm.

Balancing anti-cancer with psychoactive

In principle, patients treated with THC соuld еxреriеnсе ѕоmе psychoactive асtivitу. But thе secret tо ѕuссеѕѕfullу еxрlоiting cannabinoids аѕ a treatment fоr cancer iѕ tо bаlаnсе the dеѕirеd аnti-саnсеr еffесtѕ with the lеѕѕ dеѕirаblе рѕусhоасtivе effects. Thiѕ iѕ possible, as some саnnаbinоidѕ seem to funсtiоn indереndеntlу оf the rесерtоrѕ аnd ѕо dо nоt engage thе adverse еffесtѕ. CBD is оnе such саnnаbinоid. Thе dоѕеѕ оf THC we еd were bеlоw the рѕусhоасtivе level, but tоgеthеr with CBD it раrtnеrеd well tо givе thе bеѕt overall аnti-саnсеr еffесt.

Our results showed that thе dose оf irrаdiаtiоn wе uѕеd had nо drаmаtiс еffесt оn tumоur growth, whеrеаѕ CBD аnd THC administered tоgеthеr mаrginаllу rеduсеd tumоur рrоgrеѕѕiоn. Hоwеvеr, combining thе саnnаbinоidѕ with irrаdiаtiоn furthеr imреdеd thе rаtе аt which tumour growth progressed аnd was virtuаllу stagnant thrоughоut thе course оf thе trеаtmеnt. Correspondingly, tumоur ѕizеѕ оn the finаl day of thе ѕtudу wеrе significantly ѕmаllеr in thеѕе ѕubjесtѕ соmраrеd with any оf thе оthеrѕ.

Thе results are рrоmiѕing. Thеrе may bе оthеr applications but fоr now it соuld рrоvidе a wау оf brеаking thrоugh glioma аnd ѕаving mоrе livеѕ.

Diet and Training

Life is too short to be average. If you’ve been searching for the only program created for those who are after hard-core health, diet and training, then taking the next minute to read this message may be the smartest thing you ever do.

You see, most health and training books are aimed at the AVERAGE person. The kind of person who doesn’t really want to change the way they eat or do any real exercise in the first place.

Stuff that! If you’re reading this then I’d be willing to bet being average is the last thing you want, right? Wouldn’t you rather go through life standing out from the crowd, hell, you don’t need to live life as the average soft unfit slob most people are today!

WARNING: But if you’re not interested in any of the listed topics on the right (the ones you need to tick) then please don’t waste both of our time. I suggest continue surfing the web for a less hardcore or ‘easier’ program.

But, if you too are sick of ‘moderation’, and if you believe “YOUR life is too short to be Average!” A radical elite system designed to cut out all the bulls$#t and go straight for the jugular is needed.

Greetings, my name is Anthony Bova, but you can go ahead and simply call me Bova or the Spartan Warlord, everyone does. I’m the infamous author of this controversial hard-core “Spartan Health Regime” program.

(If you want to know why I’m called the Spartan Warlord then go ahead and download the 1st Chapter of my Spartan program below for FREE right now to find out . . . .)

You may have seen one of my past ads or articles in such magazines as Men’s Health, FHM, Muscle&Fitness, Penthouse or one of a many different worldwide Martial Art mags like Blackbelt or Blitz etc.

Or, maybe you were referred by a friend or training partner who is already using the Spartan program. You may even have stumbled across this site purely by accident!

But no matter how you found this site congratulations are in order, because for a limited time I have a very special gift for you. I want to give you absolutely FREE the complete, unedited 1st Chapter of my revolutionary Spartan program – no strings attached . . .

But first, let me ask you a tough personal question . . .

When you stand naked in front of a mirror are you happy with your reflection??

In fact let me ask you a few more, go ahead and answer honestly . . . .
Are you embarrassed to take your shirt off in public, say at the beach or a friends pool party? Do you try and watch your diet and eat healthy but still find your own health isn’t all it could be? Do you catch colds a couple of times a year that seem to hang around for weeks at a time? Do you have trouble staying motivated with your diet and training? Do you have a stubborn layer of fat around your stomach? Are you unhappy with your progress in the gym and strength?

Just a few years ago I had all of the above problems myself. I felt like my life was going by fast but I wasn’t living it in the body I wanted – maybe you feel the same way? I read every book and magazine on health, diet and training I could get my hands on but I just never got the results I wanted. I was doing what all the experts told me to, why wasn’t it working?

To make a long story short I found the answers to all my problems. A diet and training system so powerful it changed my life for ever. And now YOU can use it too!

The Spartan Health Regime is a complete health, diet and training system unlike anything else around. Using this system I lost that stubborn layer of fat around my stomach. I haven’t had a cold since. I built a lean, powerful fit body I am very proud of. I added muscle faster than I thought possible and I’m not talking about the pumped-up-but-useless muscle all those drug-monsters build.

For example, to celebrate my cousins birthday I picked him up and lifted him over my head half a dozen times (great party trick). But I also now have the endurance to run at top speed for over an hour. Most importantly my confidence and self esteem have improved dramatically, making life a whole lot happier.

Once you have participated in this program the next step is to decalcify your pineal gland by adjusting your diet even further by taking steps to remove  the fluoride.  The first step of this exciting program is the heavy metal detox. any way more news about this program later.

And I’ve done the same thing over the last 9 years for close to 9,887 dedicated martial artists, weight trainers, armed forces personnel, football players, triathaletes, runners and health & fitness fanatics from around the world.

38 Park Avenue IT Park Cebu


Condos For Sale Cebu by 38 Park Avenue

A superb property currently in the pre-selling phase will be starting shortly once 100 units are pre sold

The off plan prices are as you would expect discounted to give the 100 investors instant equity as well as giving them 48 months to pay their deposit at 0% interest.

The 38 Park avenue Cebu property development has 2 phases the first is the residential tower and external amenities and the second being the commercial tower

If you are looking for a great investment opportunity then you should consider 38 Park Avenue and visit their website for more details especially about the specifications and features.

Lettings Agency in Leeds’ video

This a Belvoir: Leeds Lettings Agent corporate video

Belvoir is a franchise operation and has a strong brand image as the premier lettings agent in which ever area they operate. In the last 12 months has expanded it number of branched from 250 to 320 through out the UK. Belvoir have now entered the market place as Morley estate agents as well and letting agents in South Leeds. This will increase the groups revenues dramatically with out much additional cost.

Due to their connections with the Lettings sector it is conceivable that their niche market in the Estate Agency sector will be for those Landlords who wish to buy to let and now, for those with disposable cash is an ideal time to buy. other companies such as homes in Cebu who are a relatively newcomer to the Property for sale industry do not have videos on their website yet other than those provided by the developers

Best Hgh Supplements as Injection

Hgh Supplements as Injection

The use of HGH for sale injection is proffered by many because of the less knowledge about the side effects. These injections come with high risk of overdose and that can result in bigger bones and stretch muscles. These are really harmful along with the fact that these injections cost a lot. You must not take any chance with the HGH supplements and the required dose. If you think that using the supplements more than the prescribed amount will help you to get fast and better results then that’s a mistake that you are making. What you need is the right supplement to take in right amount regularly. Too much of HGH release is not good for your health.

I conducted a study on different popular hgh supplements pills, and their effects on human body.

It was a great pleasure when I found most of the hgh supplements can works smoothly without any side effects and able to make positive results. But I need to concluded the best one.

I took consideration on the following facts to make the study for finding out best hgh supplement

Ingredients of different hgh supplements

Doses
Age
Gender
Side Effects
Money back guarantee
Old disease
Users feedback

After the above study I started to bio-chemical study of each ingredient, and finally I concluded that, HGH uk Supplement definitely help you to restore your energy level, body fitness, body mass improvement without any side effects. But it is not a magic bullet to serve you over the expectation.

Best Eradication of Skin Mole

Mole Eradication With Home Healing

If perhaps you’ve got a skin mole that you do not like it might appear that you’re left with very few choices because skin mole treatment is concerned. Removing a mole from your body by using any mole removal or even mole removal cream can’t only be dangerous but it can leave you with a scar that looks a whole lot worse than the skin mole that was there in the first place depending on how you manage by treating it. Another thing that you need to understand is that not all skin moles are the same.

Actually, if you were to speak to any dermatologist they’d explain how many times moles are tell tale indicators that some thing is wrong. If the mole is abnormal in shape and even size or if it changes quickly and bleeds it might be a proof of something that is wrong. However do you know the ways for mole treatment?

Only some time ago I believed that the only ways for skin mole elimination may be found in the dermatologist’s office. I watched as my spouse had a few serious moles eradicated from her by means of freezing and surgical procedures. The one mole that they removed created a permanent scar tissue on her shoulder that continues to have some pain even a few years later.

Luckily there are other ways of eliminating skin moles besides having your health care professional cut them off or freeze them. There are home techniques which can be obtained by searching online that will not only eradicate the mole from the body but will do this with virtually no medical care or perhaps surgery and will leave no visible scars on your skin.

Body to body Best Naked

Best Body to body massage by naked therapist

Erotic massage in London is not for everyone. It is admittedly only for the elite, for the true connoisseurs of sensory experience, of luxurious indulgence, of the finest thing in life… Unparalleled in its ability to deliver the most delicate erotic sensations, tantric massage London is for those who dare to explore the unknown and to push the limits of ordinary in their search for supremacy and perfection.

Naked body to body massage aims to arouse a man to the highest by employing a wide range of sophisticated caresses, teasing strokes and provocative bodily moves. Purposefully accumulating sexual arousal, erotic and tantric massage therapist will then carefully direct the energy, trying to align it properly along the energy lines and meridians of the body and harmonizing its flow.

Best Massage

WHAT IS A MASSAGE?

Massage is a scientific method that involves the treatment of superficial areas of the body -that may include muscles, tendons, ligaments, skin, joints, or other connective tissue, as well as lymphatic vessels and organs of the gastrointestinal system; with physical, therapeutic and emotional purposes. Etymologically, the word comes from French and its literal meaning is “friction of kneading”.

The patient’s body is manipulated trough rubbing, kneading, stroking, slapping or vibration which can be structured or not depending of the modality of the massage (There are more than a hundred forms including the Eastern styles that are based on the body’s energy such as Acupressure; and the Western styles that are focused on anatomical knowledge like Swedish massage). The pressure applied is done with the hands, fingers, elbows, forearm, and feet, or employing any of the various mechanical devices.

Medical researches have proven that the benefits of massage include pain relief, released tension, reduced anxiety and depression, and temporarily decreased blood pressure and heart rate. In general, massage promotes relaxation and integral well-being. Scientifically, it is possible because massages may block pain signals to the brain, activating the parasympathetic nervous system which stimulates the release of endorphins and serotonin, preventing damage on the connective tissue and boosting the circulation of lymph.

Massage in Chelsea is performed by specialized Massage Practitioners and by other health care professionals, like: Physical Therapists, Athletic Trainers, Chiropractors, Osteopaths, etc. Massage therapists can be found in hospitals, nursing homes, fitness facilities, spas, beauty salons and many other places. Massage sessions involves the patient being treated while lying on a massage table, sitting upright in a massage chair, or lying on a pad on the floor. The massage subject may be fully, partly or unclothed (disrobed) and the body covered with sheets or towels.

Due to its clinical effectiveness, the massage demand has highly increased in the last decades. Chelsea Massages are useful for decreasing the symptoms of several conditions of the muscles and nervous system, like arthritis; and it is excellent providing physical and mental relaxation. However, there are some contraindications, so it is always better to consult a doctor before taking a massage. Note that each person responds in a different way to massage and there isn’t only one type which is best for all.

The Importance of HGH

HGH Is A Fundamentally Important Hormone

Human Growth hormone is a protein that is built from amino acids. It empowers the liver to make Insulin, that causes bone and tissue growth in the body. During puberty, when most body development occurs, the production of HGH is the highest. After the phase of physical development ends, HGH production reduces dramatically. HGH UK is called the master hormone, as it-

* stimulates Insulin activity,
* improves metabolism,
* induces fat reduction,
* stimulates growth,
* assists development and regeneration of cells
Overall, it has a direct impact on bones, muscles, hair, pores, skin, eyesight and memory retention.

Our body cannot distinguish the bio-identical hormone with the real thing. HGH injections for sale are good for helping children, with growth hormone deficiency. But, if given to children or adults with normal growth, HGH levels in the body become too high. This can lead to serious side effects, like-

* abnormal growth of bones, or Acromegaly
* organ enlargement
* high blood pressure
* new research also suggests a link to colorectal cancer, later in life.
* Swelling in limbs
* Carpal Tunnel Syndrome

The Use And Abuse Of HGH

Today in UK, HGH is being marketed as the “wonder drug”, the benefits offered range from a reversal of ageing process, to improved metabolism, fat loss, develop muscle mass and improve sex drive. It is being widely used in rejuvenation clinics, globally. Sportspersons use injectable HGH to enhance their performance, increase energy and muscle mass. However, HGH is a prescription medicine, not allowed to be sold over the counter. The rising demand of HGH supplements has accelerated the production and illegal sale of inferior products. You can buy HGH injections legally, provided you have a medically documented need for it. Several other products, like dietary supplements, known as HGH releasers, are widely available. There is no proof to substantiate these claims.

Caution While Taking HGH Supplements

HGH injections must be avoided if the person has cancer, is at high risk for cancer, or has a family history of the disease. The biggest issue related to injectable HGH supplements, is the human tendency to desire quick results, leading to abuse of the medication. Some athletes and body building enthusiasts, abuse HGH by injecting excessive dosages over short time gaps. The most common side effect related to excessive HGH use is Acromegaly, the overgrowth of facial bones and connective tissue. It is important to remember, that healthy lifestyle choices, like diet regulation and physical exercise are the best proven ways to make you feel good even as you grow older.

SEO in CEBU

An Easy and Right Ways of Doing SEO

Interestingly, most terms and activities surrounding the online space, especially if they are more technical in nature have two possible designations associated with them. Whitehat, and Blackhat. When it comes to a website’s visibility within search engines, those terms especially apply. It is best to remember the distinction this way: Whitehat SEO is genuine, organic, and will last for a long time, but that of course also means that it is hard work and takes dedication to build up.

– First, you need to pick a good domain name for your website, a kind of domain name that most describes what your website is actually about, and then ends with the suffix, .com, or at least .net Sure there are many websites especially now days, which seem to have a nonsensical domain ane end with .co, .io, or something like that. But it is important to keep in mind that those websites are usually popular through word-of-mouth, or because they were featured in some big magazine, not because they have implemented good white hat SEO on their website.

– Second, you need to make sure that you are actually running a content management system that is built according to good coding standards. This could be WordPress, Drupal, Ghost, Joomla, or any number of popular CMS that minify their CSS and Javascript code for better website loading speed.

– A third healthy principle with SEO is to only publish relevant, original content, which has helpful and descriptive meta-titles filled in, titles which precisely pinpoint what the content that follows them is about. A good example of this is this article in particular.

A blackhat, or illegitimate SEO approach to creating titles for clicks is that which prevails in banners that bear descriptions such as from around the web, and link to dubious articles such as An easy way to become rich overnight just by looking handsome. Google is monitoring such titles and they are pretty sure that the article behind that title is not going to deliver on its premise.

Blackhat SEO practices are those which promise to register a website into countless web directories. Nobody is visiting those directories and while this practice will in the short term create more of an internet record about your website, Google views such practices as a form of spam, especially when done very quickly in succession. While this is meant to build backlinks, commenting on other websites in your niche and exchanging ideas, or as it is simply called guest posting is a much more sure way of building an esteemed following online. Social media can be a start to creating outreach.